Year 2000 (MM) was a leap year starting on a Saturday of the Gregorian calendar.
- January 17 - Sleepy Time and Suds premiered.
- February 14 - Valentine's Day and The Paper premiered.
- March 15 - Arrgh! and Rock Bottom premiered.
- March 22 - Texas and Walking Small premiered.
- April 1 - Fools in April and Neptune's Spatula premiered.
- April 8 - Hooky and Mermaid Man and Barnacle Boy II premiered.
- October 26 - Something Smells and Bossy Boots premiered.
- November 2 - Your Shoe's Untied and Squid's Day Off premiered.
- November 16 - Big Pink Loser and Bubble Buddy premiered.
- November 27 - Grandma's Kisses and Squidville premiered.
- November 27 - Mermaid Man and Barnacle Boy III and Squirrel Jokes premiered.
- December 6 - Christmas Who? premiered.
- December 28 - Dying for Pie and Imitation Krabs premiered.